While eating a well-balanced, reduced-calorie diet and exercising regularly are the cornerstones of weight loss, certain drugs can serve as powerful adjuncts.

One such drug is phentermine — one of the most popular weight loss drugs in the world

Phentermine is a prescription weight loss medication. It was approved by the FDA in 1959 for short-term use of up to 12 weeks for people older than 16 years

It has been proven effective for short-term weight loss when used alongside a reduced-calorie diet and exercise. However, using phentermine for weight loss is not without risks and side effects

Taking phentermine helps suppress your appetite, thereby limiting how many calories you eat. Over time, this can lead to weight loss.

However, you may build a tolerance to the appetite-suppressing effects of phentermine within a few weeks. In that case, you should not increase your dose of the drug but stop using it altogether.
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Effective for Weight Loss

Several clinical studies have proven that phentermine can boost fat loss.

The expected average weight loss with phentermine use is 5% of your initial body weight. Yet, over 12 weeks, it can be as high as 10%. This equates to a weight loss of 10–20 pounds (4.5–9 kg) for a 200 pound (90.7 kg) person.

In a meta-analysis of six studies, people who took the average dose of 27.5 mg of phentermine for 13 weeks lost an average of 13.9 pounds (6.3 kg) compared to 6.2 pounds (2.8 kg) in placebo groups.

While phentermine has been shown to be effective for weight loss, it may work better when combined with topiramate.

Dosages for phentermine vary depending on its form and concentration.

Phentermine

Prior to 2016, the available doses of phentermine were 15, 30, and 37.5 mg.

However, since it’s recommended that doctors prescribe the lowest effective dose, the FDA approved an 8-mg formulation in 2016, which can be taken up to three times daily.

You should avoid taking the last dose too late in the day to prevent insomnia or difficulty falling or staying asleep.

The most commonly reported side effects include:

Dry mouth

Sleeping problems

Dizziness

Heart palpitations

Flushing of the skin

Fatigue

Constipation

If you’re using phentermine and are pregnant or nursing, the safest course is to stop immediately